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The medication is initiated at 2.5 mg once weekly for 4 weeks, serving as a tolerability dose rather than a therapeutic dose
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therefore, rapid diffusion of GSSG from the active site could be an important factor and the 2-helix dynamics may release GSSG from the active site-binding cleft to allow DHA binding
The authors conclude that GLP-1 functions as "a central node linking gut microbiota, metabolic homeostasis, tissue repair, and immune regulation," a framing that positions GLP-1 pathway intervention not as a metabolic adjunct but as a legitimate disease-modifying strategy across the spectrum of age-related musculoskeletal degeneration
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