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Ex9 had no effect on glucose tolerance in linagliptin-treated Gcg RA Null or in Gcg RA VilCre mice

The cardiovascular benefits observed with these medications include: Reduction in non-fatal myocardial infarction and stroke Decreased cardiovascular mortality in high-risk populations (demonstrated with liraglutide) Improvements in blood pressure and lipid profiles Weight reduction , which independently lowers cardiovascular risk It is important to distinguish between arterial thrombotic events (such as heart attacks and strokes, which some GLP-1 agonists help prevent) and venous thromboembolism (DVT and PE)

Efectos secundarios y seguridad: Los eventos adversos se parecen a otros agonistas incretnicos, predominando sntomas gastrointestinales: nuseas, diarrea, vmitos, estreimiento, disminucin del apetito y malestar estomacal, con dependencia de dosis