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Recently, agonists of glucagon-like peptide-1 (GLP-1) receptor, designed based on the gut hormone GLP-1, have been developed as anti-obesity drugs and have demonstrated remarkable efficacy in treating both obesity and diabetes

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This shifts clinical emphasis toward interventions with stronger evidence for preserving lean masssuch as adequate dietary protein and resistance trainingwhile complementary biological modulators like postbiotics may improve insulin sensitivity and inflammatory tone, thereby supporting metabolic resilience rather than directly increasing thermogenesis