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Oxytocin receptor expression was measured in the following brain regions: prelimbic cortex, anterior olfactory nucleus, nucleus accumbens, lateral septal nucleus, bed nucleus of stria terminalis, ventral reuniens, paraventricular and ventromedial hypothalamic nuclei, hippocampal CA1 and CA2/3 regions and the central amygdaloid nucleus

Whilst multiple factors contribute to this benefit, a reduction in vascular inflammation has been hypothesised as a potential contributing mechanism, though this remains speculative

However, significant individual variation exists based on factors such as: Body composition and weight distribution volume may differ Metabolic rate affects how quickly proteins are broken down Dose and duration of treatment higher doses and longer treatment may extend elimination time Individual patient factors age, overall health status, and concurrent medications Patients who have been taking Wegovy at the full 2.4 mg maintenance dose should expect the medication to remain active in their system for several weeks after discontinuation

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