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Briefly, an inverse correlation between IGF-1 (IGF-1/IGFBP-3 ratio) circulating levels and several markers for obesity, MetS, T2D, and CVD has been found

"Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight." Diabetes, Obesity and Metabolism , 19(9), 1242-1251