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However, synthetic LA is a racemic mixture of R and S isoforms, where S-LA can prevent the polymerization of R-LA to enhance its bioavailability (Shay et al., 2009)

This makes it particularly useful for laboratories carrying out repeated investigations where standardised handling methods are important

Their compact and chemically stable structures facilitate efficient gastrointestinal absorption, independent of dietary restrictions, which simplifies both patient administration and large-scale manufacturing

In addition, metformin could regulate DNA/histone modifications and miRNAs to carry out transcriptional regulatory processes (