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These two IE proteins are the switches of the lysis phase, switching on the entire viral replication cascade
Submitted a protocol and held an end-of-Phase 2 meeting with the FDA regarding a Phase 3 trial of TransCon CNP and TransCon hGH in pediatric achondroplasia
Room temperature storage: short shelf life Room temperature stability (lyophilized powder): Why room temperature is risky: Degradation accelerates dramatically 10C warmer = 2x faster degradation 20C warmer (room temp vs freezer) = 4x faster Moisture in air can affect powder Bacterial spores can colonize When peptides are at room temperature: During shipping (1-3 days typically) After delivery before refrigerating When reconstituting (brief exposure) Minimize room temp exposure: Refrigerate or freeze immediately upon receipt Don't leave out while reconstituting (work quickly) If traveling, use cooler with ice packs Never store at room temp intentionally Shipping concerns: Most peptides survive 1-3 days room temp shipping Hot summer shipping can damage peptides Request cold packing in summer Overnight shipping better than standard Use SeekPeptides to track peptide storage duration and get alerts when approaching expiration
Similarly, individual clinical trials reported minimal or no AEs (Sato 2020
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