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Effects of flavonoid-rich beverages on prostacyclin synthesis in humans and human aortic endothelial cells: association with ex vivo platelet function

Thus, studies suggest that PQQ may be beneficial in insulin resistance and type 2 diabetes ( in vivo and in vitro , regulated by the NLRP3 inflammasome ( PQQ showed protective effects on lipotoxicity and inflammation caused by maternal obesity, and intervention on the risk of NAFLD (Zhou et al., 2021)

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Most trials are still ongoing and only one prospective randomized clinical trial with a primary outcome of major cardiovascular events in patients with T2D has reported its results [28]