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Starting with a lower dose of inositol and slowly increasing it under medical supervision is often the best approach to minimize these issues

Notably, thyroid hormones may facilitate augmented carnitine synthesis in the liver by increasing -butyrobetaine hydroxylase (BBD) activity and gene expression, which may constitute a feedback regulatory loop between thyroid hormones and carnitine [80]

Starting at a higher dose or increasing the dose too quickly can increase the risk of adverse events and side effects

Headache, nasopharyngitis, and upper respiratory tract infection were the most frequently reported events across all dose groups