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Prednisone reliably worsens glucose homeostasis through hepatic gluconeogenesis stimulation, peripheral insulin resistance, and direct beta-cell suppression
However, when combined with insulin or sulfonylureas, dose reduction of these agents may be necessary [6]
The combined 8mg groups in the trial lost 22.8% of body weight at 48 weeks, with 100% of participants achieving at least 5% weight loss and 91% achieving 10% or more
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