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however, in acute cutaneous lupus erythematosus where the rash has faded, DIF will still be positive in 70-80% of cases if the biopsy is taken from sun-exposed skin Management General measures Provide a patient information leaflet on either discoid lupus erythematosus or subacute cutaneous lupus erythematosus Provide a patient information leaflet on UV protection Advise on stopping smoking Consider vitamin D supplementation DLE (chronic cutaneous) and SCLE Are generally managed by specialists - effective treatment is required to reduce the scarring caused by DLE First-line treatment - topical A potent topical steroid (eg betnovate ), or, occasionally a superpotent topical steroid (eg dermovate ) should be applied thinly and accurately to the plaques

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Maintenance dosing: After reaching target doses through escalation, maintenance protocols continue at stable levels

Clinical results: The SURMOUNT-1 trial, published in the New England Journal of Medicine, showed tirzepatide produced average weight loss of 20.9 percent at the 15 mg dose