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These results have been confirmed in real-world population studies [85, 86] and by metanalyses performed on available data [79, 87]

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Less body weight means less compressive load on the knee with every step Adipose tissue produces inflammatory signalling molecules (IL-6 and TNF-alpha) that drive joint pain, and reducing fat tissue reduces those signals 3 The IDEA trial in 2013 demonstrated clinically meaningful reductions in pain through diet and exercise alone, without any GLP-1 medication 3 Whether semaglutide also has anti-inflammatory effects independent of weight loss, through GLP-1 receptors on immune cells, is a separate question

This is usually accompanied by other symptoms such as a widespread rash, hives, or swelling of the face and throat