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Under pro-inflammatory conditions, as evidenced by interventions with LPS or IFN-, microglia are insensitive to ferroptosis, yet susceptible to iron overload ( in vitro data showed that genetic depletion of iNOS renders Raw264.7 cells and EOC 20 cells vulnerable to ferroptosis, whereas NO donors (SNAP, DPTA-NONOate) empower the ferroptotic resistance of M2 microglia (43)
Also, Han et al
The tumor suppressor PRDM5 regulates Wnt signaling at early stages of zebrafish development
Adults with deficiency saw big improvements in symptoms
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