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Our notable exception is the observation in several studies that NAC is highly effective in elevating glutathione (GSH) under conditions where there has been a dramatic (acute depletion) drop in intracellular glutathione (GSH) levels, for instance as is the case in acetaminophen overdose
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This mechanistic complexity, coupled with the translational gap between animal models and clinical practice, has repeatedly undermined single-target strategies and continues to limit the development of effective therapies
Evdokimova V, Tognon CE, Benatar T, Yang W, Krutikov K, Pollak M, et al
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