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Discussion In this post hoc analysis of two randomized placebo-controlled clinical trials in participants who had overweight or obesity without or with type 2 diabetes, tirzepatide was associated with a reduction in albuminuria, particularly among participants with elevated albuminuria at the start of the study
In standard functional assays, orforglipron shows greater than 100-fold selectivity for the GLP-1 receptor over the glucagon receptor, the GIP receptor, and the secretin receptor
doi: 10.2741/S415, 3
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