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Glutathione depletion has been documented in several neurodegenerative conditions
Patients taking certain medications (e.g., chloramphenicol may reduce the effectiveness of B12 therapy) or with risk factors for B12 deficiency (metformin use, proton pump inhibitors, nitrous oxide exposure, vegan diet) should discuss these with their healthcare provider
Metals stored in tissues release gradually, requiring consistent glutathione support
These adaptations may explain why metabolic benefits can continue to improve over weeks to months of consistent use, rather than plateauing immediately
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