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(2017) employed the model of the glucose and glutamine metabolism and reported that, when oxygen conditions are insufficient to fully oxidise the available glucose and glutamine carbons (as in the environment of proliferating cells), redox homeostasis can be maintained through switching on alternative metabolic pathways, like utilising glutamine through reductive carboxylation which results in lipid production
Mechanistically, p53 forms a complex with DPP4 and promotes the nuclear accumulation of DPP4
The role of oxidative stress and antioxidants in diabetic complications
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