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Yes, GLP-1 must be refrigerated between 36F and 46F (2C to 8C)
[2] [3] NICE guidance (NG28) recommends GLP-1 receptor agonists for adults with type 2 diabetes who have inadequate glycaemic control despite optimal management with metformin and other oral agents, particularly when significant weight loss would be beneficial
Over 68 weeks, the semaglutide group lost an average of 14.9 percent of body weight versus 2.4 percent on placebo
Cardiovascular safety outcome trials included patients with T2DM and either established CV disease or multiple CV risk factors (and albuminuria or impaired renal function in CARMELINA)
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