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Pre-clinical studies in genetically modified animal model of T2DM (OLETF rats, Otsuka Long Evans Tokushima fatty rats) have shown high PRA (plasmatic renin activity) levels, without any change in aldosterone levels under dapagliflozin chronic treatment, in accordance with the aforementioned observations of an independent intrarenal RAS (36)
Diabetes UK: What Is Diabetes Distress and Burnout
Stazi M, Lehmann S, Sakib MS, Pena-Centeno T, Bschgens L, Fischer A et al (2021) Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis
2024;19(4):e0300544
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