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We then applied this signature in STEP 2, an external validation set, in which it showed similar performance for distinguishing semaglutide treatment from placebo (AUC = 0.93) (Extended Data Fig

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Admission at a liver transplant facility is important for patients who develop signs of acute liver failure, which include encephalopathy, coagulopathy and metabolic acidosis

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But for an athlete, this same powerful mechanism raises immediate red flags for anti-doping authorities

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