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Frontiers in pharmacology , 11 , 579944
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In the Phase 2 trial, participants who started directly at 4 mg (without the 2 mg titration period) experienced nearly double the rate of gastrointestinal adverse events compared to those who started at 2 mg (Jastreboff et al., NEJM 2023)
Splitting the dose maintains more consistent tissue levels given BPC-157s relatively short half-life of 4 to 6 hours
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