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Additionally, a meta-analysis confirmed the efficacy of omega-3 supplementation on the duration of the migraine attacks (137)
The electron-withdrawing character and steric bulk of the -amino isobutyric acid residue abolish interactions with the dipeptidyl peptidase 4 active site, rendering the peptide completely refractory to enzymatic degradation [6] [11]
In contrast, over-the-counter patches are regulated as dietary supplements
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