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Exp Biol Med (Maywood)
J Obes Weight Loss Ther
## Combining Semaglutide with Supportive Therapies One advantage of transitioning from AOD-9604 to a GLP-1 **weight loss peptide** is the ability to complement the protocol with well-studied supportive therapies: ### NAD+ for Metabolic and Anti-Aging Support [NAD+ injections](/guides/nad-injection-benefits-anti-aging-energy-recovery-guide) support mitochondrial function, cellular energy production, and DNA repair all of which may be beneficial during active **fat loss**
The 100mg cohort showed statistically significant reductions in visceral adipose tissue (8.3% vs baseline) and improvements in insulin sensitivity (HOMA-IR reduction of 18.7%), but no hepatotoxicity signals emerged across any dose tier
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