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By coupling agonism at the GLP-1 receptor with simultaneous agonism at the GIP receptor, a related incretin whose physiological role had been the subject of decades of competing theories, Eli Lilly produced a molecule whose efficacy in trial conditions exceeded semaglutide by a margin too large to dismiss as noise or trial-design artifact
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![GLP-1 Weight-Loss Medication Glucagon-like peptide-1 (GLP-1) receptor agonists (semaglutide [Wegovy, Ozempic, Rybelsus]) and dual incretin agonists (tirzepatide [Zepbound, Mounjaro]) are popular treatments for obesity. The authors discuss the kind of](https://lookaside.fbsbx.com/lookaside/crawler/media/?media_id=1050961973852737)
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