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Rodent studies often employ controlled ethanol administration regimens, whereas human drinking behavior is influenced by sociocultural factors, polysubstance use, and fluctuating motivation

Masaki A, Ishida T, Maeda Y, Ito A, Suzuki S, Narita T, et al

Notably, nearly half are processed by CYP3A4 and CYP3A5 specifically, with another quarter handled by CYP2C8 or CYP2C9 Conversely, drugs containing a carboxylic acid functional group may pose a lower risk of DILI, as they are typically metabolized to acyl glucuronides that are readily excreted ( Fig

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