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19 Under oxidative stress, the glutathione (GSH) level in cardiomyocytes decreases by 6070%, and the levels of Gln, glutamate and -ketoglutarate (-KG) also decrease significantly, while the enzyme activity of GLS, which converts Gln to glutamate, is enhanced
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However, some issues remain to be resolved, and a few of these are now briefly considered
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