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Specifically, confidence is considered high if supportive evidence derives from multiple RCTs and observational studies, medium if the evidence derives from conflicting RCTs or compelling observational studies, and low if the evidence derives from observational studies only
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Pharmacol Rev (2008) 60:470512
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The risks of direct-to-consumer weight management The same can hold true for patients seeking care from an increasing number of direct-to-consumer weight management companies
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