Retatrutide and tirzepatide both work by copying natural hormones produced by your body, sending signals to your brain and digestive system
Recently, several retrospective studies of patients with T2D and CKD found that although use of GLP1-RA was associated with improved overall survival compared to use of DPP4i, there was no significant difference in cardiovascular outcomes 42,43
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Skipping doses or extending the interval to every two weeks creates gaps in appetite signaling suppression, reducing the drug's effectiveness at lowering hunger and food intake