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Enrollees underwent random allocation in a 2:1:1:1:1:2:2 distribution to receive weekly subcutaneous retatrutide at doses of 1, 4 mg (starting dose 2 mg), 4 mg (starting dose 4 mg), 8 mg (starting dose 2 mg), 8 mg (starting dose 4 mg), or vs
It has also been shown to increase growth hormone receptor expression in tendon fibroblasts (Gwyer et al., Growth Horm IGF Res 2019), amplifying the repair mechanisms
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This final suspension was aliquoted into 1ml vials and stored at -20C for 1 hour and then stored to -80C until used for in vitro granulomas formation and infection studies
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