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In diversi protocolli sperimentali non stata identificata una dose letale (LD50) chiara entro i limiti testati, un dato che ha alimentato la reputazione di "peptide ben tollerato"
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Non sono state osservate evidenze di effetti avversi ormonali, epatici o sistemici nei dati disponibili
However, some mild side effects may occur, especially during the adjustment period or at higher doses: Headaches Temporary injection site irritation Lightheadedness Water retention (in rare cases) Mild tingling or numbness (from elevated IGF-1) Ipamorelin induced growth hormone release without elevating cortisol or ACTH levels, suggesting minimal off-target effects. Raun et al., European Journal of Endocrinology Compared to Other Peptides Unlike GHRP6 , which often causes intense hunger and spikes in prolactin , or GHRP2 , which can increase cortisol , Ipamorelin is more targeted and stable
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