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Unfortunately, IGF-1 LR3 may lead to other adverse reactions similar to those related to insulin-like growth factor 1, like stimulating the growth of existing tumors, acromegaly, and organ enlargement
The research remains confined to small early-phase studies
Moreover, GLUD1 methylation was elevated in DTX-resistant cells, suggesting that GLUD1 methylation may contribute to chemoresistance and that its inhibition can enhance docetaxel efficacy
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