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Various structural alterations were made at the N-terminal such as substitution of D-norleucine for L-norleucine, N-acetylation of norleucine, and replacement of norleucine with GABA in order to improve overall stability by reducing susceptibility to aminopeptidases

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A personalized treatment plan may include: progressive strengthening exercises physiotherapy flexibility and mobility training activity modification weight management where appropriate nutritional support regenerative therapies when clinically indicated regular follow-up to monitor progress For athletes, rehabilitation may emphasize restoring strength, balance, and sport-specific movement patterns before returning to competition

MOTS-c activates AMPK to improve metabolic function, fat oxidation, and mitochondrial biogenesis