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GLP-1 medications, such as semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro, Zepbound), were originally developed for type 2 diabetes and later approved for chronic weight management at full therapeutic doses
Shown to improve epithelial barrier integrity, reducing gut permeability and inflammatory cell infiltration
These effects occur at the expense of a slight increase in hypoglycemia, but careful titration of insulin doses may mitigate this risk
For therapeutic benefits to accumulate especially for fat metabolism or liver health a course of sessions is typically recommended
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