In order for this 'factory line' of methylation to work these B vitamins have to be in their active form
And its been shown to be effective in adults as well as children
Generalized pain, Deep aching pain, Sharp stabbing pain Brain fog, Irritability, Anxiety, Mood swings Insomnia, Restless leg syndrome Pain and stiffness after waking or sitting for a period Nausea, decreased morning appetite Sensitive teeth Fatigue, Chronic fatigue syndrome (ME/CFS), Exercise intolerance, Pain worsened by exercise Cold hands and feet, decreased capillary refill
It was a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial at 57 sites in ten countries (Canada, Denmark, Finland, Ireland, Japan, Poland, Serbia, South Africa, the UK, and the USA)