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However, the coexistence of micro and macrovascular disease is associated with the highest cardiovascular risks which highlights the importance that pharmacological treatment of type 2 diabetes mellitus provides not only glycemic control, but also cardiovascular safety

The authors also thank Michael V Sofroniew (University of California Los Angeles) for providing the GFAP-Cre mice, and Shigeyoshi Itohara for providing CaMKII-Cre mice