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The first drug targeting the GLP-1 receptor was exenatide, released in 2005 as a twice-daily injection to treat type II diabetes

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The activated NLRP3 inflammasome converted pro-caspase-1 to active caspase-1, which promoted the maturation and secretion of IL-18 and IL-1 and triggered the inflammatory and immune responses (Martinon et al., 2002