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Two decades-long journey from riluzole to edaravone: revisiting the clinical pharmacokinetics of the only two amyotrophic lateral sclerosis therapeutics
Gut microbiota modification via glucagon-like peptide-1 with beneficial neuroprotective effects
taken orally as a mixed powder, capsule, or ready-to-drink dose, generally used continuously or in 8-12 week cycles to assess effect Pros: Widely available, inexpensive, and legal over-the-counter with no prescription needed Strong safety track record from decades of dietary use Supported by multiple randomized controlled trials for skin hydration/elasticity and joint comfort Cons: Effect sizes are often modest and some trials show outcomes close to placebo Requires weeks to months of consistent daily use before noticeable benefit Not a substitute for injury-specific treatment in acute or severe injuries Side Effects: Generally well tolerated
Lucaci AG, Notaras MJ, Kosakovsky Pond SL, Colak D (2022) The evolution of BDNF is defined by strict purifying selection and prodomain spatial coevolution, but what does it mean for human brain disease
