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Similarly, the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) [47] and the Study of Heart and Kidney Protection with Empagliflozin (EMPA-KIDNEY) [48] trials expanded inclusion beyond diabetes mellitus, showing that dapagliflozin and empagliflozin significantly reduced the risk of kidney outcomes, with consistent benefits across a wide range of eGFR and albuminuria
TrimRx, MEDVi, Eden Health, Willow, and MyStart Health all use licensed U.S
Trial Registration ClinicalTrials.gov identifiers NCT02172313, NCT01572753
This makes sense since both molecules are designed to activate the GLP1 Receptor (receptor activation is based on molecule shape): If the impurity does not have similar molecular characteristics as the target, it will not show up in HPLC analysis
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