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What are the known side effects of retatrutide from clinical trials
By activating peripheral and central GLP-1 receptors, they modulate appetite-related neurohormonal signalsincluding insulin and leptinand regulate adipocyte metabolism, thereby contributing to sustained weight loss 20,21
For tirzepatide (Zepbound, Mounjaro), the SURMOUNT-1 withdrawal substudy showed comparable results: patients who discontinued after 36 weeks regained 14% of body weight over the next 52 weeks, returning nearly all lost weight
Both peptides stimulate growth hormone release, but tesamorelin works by mimicking GHRH, while ipamorelin mimics ghrelin
