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Studies are ongoing into the reasons for this, but many scientists believe there is a link between low glutathione levels and cell death

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We propose that the requirement of two distinct glutathione interaction sites for the efficient reduction of glutathionylated disulfide substrates explains the deviating structurefunction relationships, activities and substrate preferences of different glutaredoxin subfamilies as well as thioredoxins

Suffice to say that some or all of these are, generally, part of a rehabilitation programme, such as those set up by PeRiHab