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Specifically, the decrease in SIRT1 levels, inhibition of its activity, or generation of mutations that lower its activity have been linked to intestinal inflammation and colitis in human and rodent models (Wellman et al., 2017)
Glutathione treatment also decreased protein-bound glutathione to normal baseline levels
Patients with chronic pancreatitis have lower levels of glutathione, cysteine, and glycine.[ref] Increasing cysteine levels with NAC is protective against pancreatic damage.[ref] Schizophrenia: Several research studies show that people with schizophrenia have lower glutathione levels in certain regions of the brain.[ref] In aging: The studies on glutathione in aging show that there is usually a general decrease in serum glutathione levels as we age
