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Abdominal bloating decreases (partly from visceral fat reduction, partly from reduced inflammation in adipose tissue)
Like semaglutide, tirzepatide helps regulate blood sugar levels, reduces appetite, and promotes weight loss by influencing metabolism and signaling in the body
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Secondly, significant weight loss and the resultant change in the inflammatory phenotype of obese adipose tissue would reduce the release into the circulation of key pro-fibrotic pro-inflammatory cytokines/adipokines such as TNF-, IL-6, leptin [31], visfatin and resistin, and increase levels of anti-fibrotic adipokines such as adiponectin [32]
Pathogens or cellular debris induce heightened expression of pro-inflammatory cytokines such as IFNs and LPS, prompting microglial activation from a resting state (47)
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