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GLP-1RAs and heart failure The prevalence of left ventricular ejection fraction (LVEF)-preserved heart failure continues to increase

Additionally, lixisenatide and liraglutide are available in combination pens with long-acting insulin under the brand names of Soliqua and Xultophy

The biological mechanisms that drive weight regain, including hormonal adaptations, metabolic rate reduction, and neurological changes in appetite regulation, persist indefinitely