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Patients may only receive retatrutide through: Approved clinical trials registered with the MHRA and listed on the ISRCTN or ClinicalTrials.gov registries The MHRA Early Access to Medicines Scheme (EAMS) or compassionate use programmes, which allow access to promising unlicensed medicines for patients with serious conditions where no adequate alternative exists however, no such route is currently in place for retatrutide , and patients should not assume access is available outside of a formal trial It is strongly advised that patients do not attempt to source retatrutide through unregulated online pharmacies or grey-market suppliers

Some patients alternate during shortages or adjust based on preferenceWegovy's fixed pens versus PlexusDx's flexible dosing