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So these are exciting times because in a lot of ways -- these drugs both treat and prevent disease. And when it comes to exactly how much weight patients are losing on semaglutide drugs, the numbers are frankly astounding

Mechanism of Action Comparison IGF-1 LR3 Reduced IGFBP-1, -2, -3 binding affinity Extended circulating half-life (~20-30 hours) Sustained IGF-1 receptor activation Full receptor binding affinity maintained IGF-1 DES Reduced IGFBP binding via truncation Short half-life (~20-30 minutes) Rapid, acute receptor activation Enhanced receptor binding potency reported Research Applications Comparison The choice between IGF-1 LR3 and IGF-1 DES depends on the specific temporal requirements of your research

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