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In in vitro cell experiments using 3T3L1 preadipocytes as a model, treatment with NNMTi significantly reduced preadipocyte differentiation efficiency and markedly downregulated the expression of adipocyte markers (such as PPAR and C/EBP) in a dosedependent manner
Fraternale A, Brundu S, Magnani M
This inflammatory synovial fibroblast phenotype exacerbates cartilage degeneration, via the induction of matrix metalloproteases (MMPs) and aggrecanases (ADAMTS4/5), and sensitises the growth and activity of joint nociceptors [92,93,94]
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