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In theory, ingredients like high-concentration L-ascorbic acid (vitamin C) or strong alpha-hydroxy acids can alter the pH environment and may interfere with the copper-peptide complex or compound irritation when applied at the same time
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Community-reported (anecdotal): headache, brain fog or mental fatigue, irritability, anxiety, nausea or other GI upset, appetite and sleep changes, blood-pressure changes, and skin reactions with transdermal-DMSO use
Experimental studies demonstrated that modulation of NNMT pathways could influence metabolic signaling networks involved in cellular energy utilization and body composition regulation
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