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Activation of these receptors by GLP-1R agonists has been shown to confer protection against microvascular damage, particularly in models of diabetic retinopathy and stroke
This glucagon-like peptide-1 (GLP-1) receptor agonist encourages insulin secretion from the pancreas, slows gastric emptying, and reduces appetite, resulting in higher energy expenditure and lower food consumption
Zweck E, Westenfeld R, Szendroedi J
3.2 Therapeutic potential in obesity Although the incretin effects of GIPR undoubtedly play a crucial role in preventing postprandial glucose excursion, there is still intensive debate on whether the GIPR should be activated or inhibited for the treatment of obesity
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