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2 Methods 2.1 Eligibility criteria This meta-analysis was registered prospectively in PROSPERO (CRD420251147337) and was carried out following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) recommendations

The fat-metabolizing effects of the MIC complex work best when the injections are given consistently over a period of several weeks to months

Inhibitory effects of peripheral administration of exendin-4 on food intake are attenuated by lesions of the central nucleus of amygdala