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Which brings the story to the FDA vote
The discovery of BRAF mutations catalyzed the development of targeted therapies, significantly improving patient outcomes ( Figure 2 The approval of the BRAF inhibitor vemurafenib marked a significant advancement in the treatment of metastatic melanoma harboring BRAF V600 mutations ( In addition to their use in metastatic melanoma, BRAF and MEK inhibitors have also been explored in the adjuvant setting
Wegovy (2.4mg per dose, 4 injections) in the U.S., Germany, and Netherlands
Full names for all the enzymes and substrates are given in Additional File 1
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